New Haven, Connecticut

the innovation

To treat cancers and other difficult diseases, Arvinas is developing a new class of drugs called PROTACs (proteolysis-targeting chimeras). They engage the body’s natural protein disposal system, the ubiquitin/proteasome system, which routinely removes damaged proteins. PROTACs degrade disease-causing proteins and then are released to continue their seek-and-destroy mission.

Craig Crews, Yale University Professor of Molecular, Cellular and Developmental Biology, founded Arvinas in 2012, using technology licensed from Yale.

the support and resources
  • An infusion of $57M through Series A & B
  • $15.3M Series A investment round
  • $41.6M Series B investment round
  • Connecticut Innovations, DECD and private venture capital
    firms all participated
  • CI has invested $2,143,793 to date
  • DECD has provided a $2.5M loan for R&D
  • $3.25M in loan financing
the outcome
  • In 2013 Nature Biotechnology named Arvinas a Top Spinout.
  • Arvinas has added 45 new employees through May 2017 and expects to add more in the future, including researchers and management, taking advantage of CTNext, the state’s innovation ecosystem, to acquire new talent.
  • Arvinas is working on multiple programs targeting several types of cancers, including prostate cancer and breast cancer. It continues to work closely with Yale University scientists.
  • The firm has forged two strategic R&D collaborations with Merck and Genentech and is exploring other diverse partnering opportunities.
“Connecticut Innovations gave us the support and the contacts we needed to move our research swiftly to commercialization. With their help, we are making strides to combat some of the most intractable diseases worldwide.”
Craig Crews, Ph.D.